CTDquerier: a tool for enrichment analysis in genetic and toxicological studies using CTD

Abstract

Biomedical studies currently include a large amount of genomic and environmental factors to study the aetiology of human diseases. R/Bioconductor projects provides several tools to perform enrichment analysis at gene-pathway level. However there is a need to perform similar analyses at gene-chemicals or gene-disease levels to provide complementary knowledge of the causal path between factors and health. While CTD provides information based on gene-disease and gene-chemical there is no software for its integration in R/Biocondcutor analysis pipelines. CTDquerier helps users to easily get and visualize CTD data in R/Biocondcutor framework. The use of the package is illustrated by enhancing a real data analysis of asthma-related genes.

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Bioinformatics
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