Extending Bioconductor To Exposome Data Analysis

Abstract

Exposome encompasses all environmental factors from conception until old age. The HELIX 'early-life exposome' approach involves combining all environmental hazards that mothers and children are exposed to, and linking this to the health, growth and development of the children. The main objectives of HELIX project include the measurement of a wide range of chemicals and physical environmental hazards in food, consumer products, water, air, noise, and the build environment. Also to define multi-pattern and individual exposure variability while determining a molecular profile and biological pathways associated with those multiple exposures. We developed a Bioconductor package (rexposome) to deal address HELIX's goals. The package incorporates functions for exploring exposome and its interaction with outcomes, its integration with different omic data as well as downstream analyses to facilitate biological insights though pathway analyses and GO terms. In this talk, the package will be introduced. Package performace will be illustrated by analyzing a subset of the HELIX’s Spanish cohort that includes 88 exposures (grouped into 13 families), methylation and gene expression data for 657 subjects. Single association analyses found that three BDEs (Polybrominated diphenyl ethers) where associated with cell development, cell differentiation, neurogenesis and axon development. Our results also reveal associations betweeen Pb (Metal) and DDT (Organochlorine) with multiple RNA regulation and metabolic processes, respectively. Our multi-omic analysis found a significant asoociation between genes RP11, RNU6 and HTR3E with particle matter.

Date
Location
Dana Farber Cancer Institute, Boston (MA), United States America